The open PETase hunt

Help find the next plastic-eating enzyme.

PETase can break down PET plastic. We’re searching for better versions—and your computer can help scan the possibilities.

Find a lead Contribute compute

This is a computational hunt: AI helps choose candidates to investigate. Only lab tests can prove an enzyme works better.

Illustrative · not a PETase structure

One search, many computers

Start a scan here. Opt in to let trusted computers help. Every candidate and score stays open to inspect.

Help find the next lead

The candidate finder

Which enzyme should we look at next?

Start with 73 distinct protein examples from PETML. Its model learned from published PETase activity measurements and ranks each candidate against the original IsPETase.

The model runs here in your browser. No account needed.

This is a first search pool supplied by the model’s authors. Its ranking is a research lead, not a measured result or a new discovery. See the model and source data ↗

Open shortlist

Run the activity model to reveal the strongest leads in this example pool.

A search anyone can join

Scan. Compare. Share the lead.

No lab coat required. Just a browser and a little spare compute.

Search possibilities

A protein model scans PETase changes and builds a shortlist of leads.

Add your computer

Choose to share spare compute. Square65 splits the search into small jobs.

Pass it on

Share the most interesting lead. The community can inspect the same evidence.

Real sequence · real model

Find a lead worth a closer look.

Scan 152 possible PETase changes. The model ranks which ones fit the protein sequence best; that gives us leads to investigate, not proof of better plastic breakdown.

First run downloads the pinned model to your browser. Then opt in to share the work across your computers. Pooled scores are checked against your local run. No lab activity or speedup is implied.

Ready when you are. Start the search on this computer.